Will the Purest Sleep Diffuser work with any essential oil? January 23, 2019 18:06 Yes, any essential oil scent can be used in the device. Related articles What comes with my Marpac Unplug mattress? What is the difference between the Rohm and Hushh? What are the electric power specs for your sound machines? What is difference between the Dohm Classic and Dohm Natural?